Cumulative toxicity tool and adverse drug reactions (ADR)

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The chart below cross-tabulates medication and Adverse Drug Reaction (ADR) risks associated with them.It can help identify actual ADRs and the risk of developing them. It identifies where an ADR may be due to a cumulative effect. Generally, the shaded areas represent side effects which are listed in SPCs as having an incidence greater than 1 in 10,000 (where the incidence is listed), or from knowledge of the mode of action of a medicine.

Please, note that the list focuses on commonly used drugs and commonly preventable ADRs, and is not meant to replace more detailed medicines information sources.

 A - STRONG anticholinergics are: dimenhydrinate, scopolamine, dicyclomine, hyoscyamine, propantheline; B - STRONG anticholinergics are: tolterodine, oxybutynin, flavoxate; C­ - STRONG anticholinergics are: amitriptyline, desipramine, doxepine, imipramine, nortriptyline, trimipramine, protriptyline; D - STRONG anticholinergics are: promethazine; E - STRONG anticholinergics are:  diphenhydramine, clemastine, chlorphenamine, hydroxyzine. Please see here for full list of anticholinergics See here for full list of medicines linked to falls. F- Amiloride side effect frequency unknown